Endocrine Abstracts

Background and Aims: to study the clinical significance of the s E- selectin (CD 62) in the serum of patients with Type 1 Diabetes and Microangiopathy (diabetic nephropathy (DN) and retinopathy (DR).Materials and Methods: 32 patients (14 men & 18 women, age mediana 26,4 years) were under supervision in the period from 1999 to 2001 years. The cohort examined was subdivided into 3 groups:1. with newly diagnosed diabetes (n = 11) ...

CD4+CD25+lymphocytes (Tregs) play a crucial role in self-tolerance and autoimmunity. LADA is associated with the loss of immune tolerance to β-cell autoantigens similar to classic type 1 diabetes mellitus. The aim of the study was to evaluate changes in terms of Tregs number and function (FOXP3 expression) in LADA patients.Material and methods: We examined 74 patients with LADA at different stages of the disease. Fifty-six healthy subjects (control ...

We estimated androgen status at 111 female patients (pts) with HH before and after hormonal therapy (HT) by estadiol 2 mg+dydrogesterone 10 mg in sequence manner not <12 months. Median age of pts was 28 y.o., mean duration of HH 6.2 year, isolated HH n=56 group 1, HH as a part of hypopituitarism n=55 group 2, 45 healthy women of the same age were included in control group. Total T, SHBG and DHEA-S levels were measured, free T levels were calculated using stan...

Objective : to estimate the activative and adhesive ability of leucocytes and endothelial cells in active PDR ( with neovascularisation ).Materials and methods : 17 young patients, age mediana 26,4 years, with Diabetes Type 1 and active PDR were compared with 17 healthy controls. ICAM-1 (CD 54) on the surface of lymphocytes and granulocytes was measured by flow cytometry ' Becton Dickinson '.Serum soluble E - selectin ( CD 62 ) was identified by ELISA ( 'R and D', UK ).Mean Di...

Objective : to estimate the activative and adhesive ability of leucocytes and endothelial cells in active PDR ( with neovascularisation ).Materials and methods : 17 young patients, age mediana 26,4 years, with Diabetes Type 1 and active PDR were compared with 17 healthy controls. ICAM-1 (CD 54) on the surface of lymphocytes and granulocytes was measured by flow cytometry ' Becton Dickinson '.Serum soluble E - selectin ( CD 62 ) was identified by ELISA ( 'R and D', UK ).Mean Di...